Flexagen manufacturers claim their joint supplement can help you “move easier, feel energized and stay active!” Everyone who has painful joints wants to feel this way, right? With so many joint supplements, it’s hard to find one that actually works—especially one with all-natural ingredients.
According to manufacturers, the “Natural anti-inflammatory and cartilage-building ingredients make Flexagen Joint Support a safe, effective alternative for joint pain relief.” As someone who prefers natural remedies to painkillers, I decided to take a deeper look into Flexagen. Are the natural ingredients proven to be effective for joint pain and discomfort?
What is Flexagen Supposed to Do?
Flexagen’s official site claims this product:
• Reduces painful inflammation
• Lubricates and cushions joints
• Supports growth of cartilage
• Improves flexibility and range of movement
These are all results people with joint pain want to see. So I researched Flexagen to see if it reduces joint pain.
Upon researching, it looks like the ingredients used in Flexagen are all proven individually to help with arthritis and joint problems. Some have anti-inflammatory properties, some have pain relieving properties, and some promote joint lubrication.
Glucosamine sulfate – In a 2001 study performed by the University of Liege, Belgium, the long term effects of glucosamine sulfate on osteoarthritis progression were tested. There were 212 participants, each of whom was randomly assigned 1500 milligrams of glucosamine or a placebo every day for 3 years.
After 3 years, the placebo group’s joints had gotten progressively worse. Those using glucosamine experienced significant joint improvement. 
MSM – A clinical study performed in 2005 proved that MSM does have a positive effect in decreasing arthritis pain. 50 participants were randomly given either 3 grams of MSM or a placebo supplement for 12 weeks.
At the end of the study, those participants who took MSM had significantly less osteoarthritis pain in their knees. The MSM did not seem to impact joint stiffness, but it did decrease pain. 
White willow bark extract – Willow bark has been used as a natural pain remedy for thousands of years. According to the University of Maryland Medical Center, Hippocrates prescribed white willow bark to his patients. He told them chewing on the bark would relieve pain and fevers.
And apparently, he was right. WebMD explains that willow bark works a lot like aspirin, and can be used for everything from muscle pain to menstrual cramps and headaches.
Boswellia serrata extract – The effect of boswellia serrata on knee arthritis was tested in a clinical study performed by the Indira Gandhi Medical College. In the study, 15 participants were given boswellia extract and 15 received a placebo. Halfway through the study, the groups were switched, so those who had previously been on the placebo then had the boswellia.
The results: all patients using the boswellia extract reported decreased knee pain as well as increased walking distance and flexibility. 
Hyaluronic Acid – This is naturally found in the body, particularly in the fluids surrounding joints. It is most effective when a doctor injects the fluid straight into the knee or other joint, rather than when taken as an oral supplement. It provides lubrication, which then decreases painful grinding or rubbing.
Cayenne pepper – This spice contains a high concentration of capsaicin, a chemical proven to provide pain relief.
Turmeric root extract – This herb is a natural anti-inflammatory, but has fewer side effects than traditional painkillers. It is safe and effective, as demonstrated by an Italian clinical study. 50 patients were given a blend of turmeric extract or a placebo supplement.
After 90 days, 58% of the participants with the turmeric blend noticed less arthritis pain and stiffness. 
While each of these ingredients has been clinically proven to help with joint problems, the amounts of these ingredients in Flexagen is not listed anywhere. These ingredients can be less effective or even ineffective for joints if proven amounts are not used.
The lack of a nutrition information label with listed amounts makes it next to impossible to know if this product blend is effective.
• Easy to swallow capsules
• Naturally-derived ingredients
• Individual ingredients are clinically proven to help with arthritis
• No ingredient amounts are listed
• No price is listed on the official website
• No user reviews online
• When you try to close the website, there are popups and it is fairly difficult to leave the page if you are not interested
Free Trial Offer
The official site advertises a 14-day trial offer. However, no free trial is really free. The small print states that you enter your credit card information to pay for shipping. Unless you return the order and cancel the auto-ship membership, the manufacturer will charge you $59.42 per month thereafter.
Pricing and Returns
Flexagen’s price is not listed openly on the official site. After reading the small print I learned Flexagen costs $59.42. The official site lists Amazon and DrugStore.com as third party sites to purchase Flexagen from, but I did not find it on either site.
The official website does not explain how to return Flexagen. Rather, it states, “for cancellations, please call Customer Service.” If you want to return Flexagen, call customer service at 888-543-7142 or email them at firstname.lastname@example.org
After doing my research, it seems like Flexagen would work well as a joint supplement. All the ingredients have been proven to work individually. However, there are no customer reviews online that say it works. The amounts of each ingredient are not listed anywhere, which makes it impossible to know how well it works.
 Reginster, JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C. “Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized , placebo-controlled clinical trial.” Lancet, 2001 Jan 27;357(9252):251-6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11214126
 Kim, L.S., Axelrod, L.J., Howard, P, Buratovich, N, Walters, R.F. “Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.” Osteoarthritis and Cartilage Journal. 2006 Mar. Volume 14, Issue 3, Pages 286-294.Available from: http://www.oarsijournal.com/article/S1063-4584%2805%2900285-2/abstract
 Kimmatkar N, Thawani V, Hingorani L, Khiyani R. “Efficacy and tolerability of Boswellia serrate extract in treatment of osteoarthritis of knee—a randomized double blind placebo controlled trial.” 2003 Jan; 10(1):3-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12622457
 “Special Turmeric Extract Benefits Osteoarthritis Patients.” Available from: http://www.medicalnewstoday.com/releases/201305.php